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September 20, 2025Open Access

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

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Authors

AOAnouk OlthofMGMelvin Noé GonzálezNPNanna Bach Poulsen

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Overview

Analysis reveals how rpb1 levels influence transcription and cell proliferation through feedback mechanisms.

Key Points

  • Cells are highly sensitive to rpb1 dosage, with a 30% reduction leading to notable effects on cell proliferation.
  • Changes in rpb1 levels induce organized gene expression alterations, contrary to random stochastic changes.
  • Sequencing and proteomic methods were utilized to investigate feedback loops involved in transcription regulation.
  • These findings suggest rpb1 is a crucial systems-level regulator of transcriptional homeostasis in cells.

Cite This Study

Olthof et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79e1dhttps://doi.org/10.1101/2025.09.18.677100
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