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August 7, 2025Annals of HematologyOpen Access

“In situ” MYC rearrangement and amplification as a secondary change in a case of High-grade B cell lymphoma with 11q aberration

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Authors

GSGioia Di StefanoSBSusanne BensAFAnja Fischer

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Overview

Case report reveals MYC rearrangement as a secondary event in high-grade B cell lymphoma with 11q aberration, implying new classification considerations.

Key Points

  • MYC rearrangement is usually considered absent in high-grade B cell lymphoma with 11q aberration.
  • This case shows MYC rearrangement occurring as a secondary change in a patient with aggressive lymphoma.
  • High-grade B cell lymphoma exhibits specific cytogenetic alterations on chromosome 11, such as copy number gains.
  • Understanding MYC rearrangement implications may change how high-grade B cell lymphomas are classified and treated.

Cite This Study

Stefano et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b746https://doi.org/10.1007/s00277-025-06433-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  2. 2Clinicopathological characteristics of high-grade B-cell lymphomas through  Bone marrow evaluation2025
  3. 3Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms2025
  4. 4RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements2025
  5. 5Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond2025 · 1 citations