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August 5, 2025PharmaceuticalsOpen Access

Emerging Strategies for Targeting Angiogenesis and the Tumor Microenvironment in Gastrointestinal Malignancies: A Comprehensive Review

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Authors

ENEmily NghiemBFBenjamin W. FriedmanNSNityanand Srivastava

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Overview

Comprehensive review highlights therapeutic strategies against angiogenesis and tumor microenvironment in gastrointestinal cancers.

Key Points

  • Main finding reveals that angiogenesis is crucial in the progression of gastrointestinal cancers.
  • Key evidence shows that current therapies struggle due to tumor microenvironment dynamics causing resistance.
  • Approach includes a systematic literature review identifying new treatment strategies like bispecific antibodies and cellular therapies.
  • Significance lies in the need for novel interventions to combat high mortality rates from aggressive gastrointestinal cancers.

Cite This Study

Nghiem et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d1258https://doi.org/10.3390/ph18081160
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  5. 5Single-cell insights into tumor microenvironment heterogeneity and plasticity: transforming precision therapy in gastrointestinal cancers2025 · 18 citations