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September 10, 2025Frontiers in ImmunologyOpen Access

Research progress on mechanisms of tumor immune microenvironment and gastrointestinal resistance to immunotherapy: mini review

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Authors

ZDZhengcheng DuanYWYangping Wu

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Overview

Mini review explores tumor immune microenvironment's role in immunotherapy resistance, suggesting new strategies.

Key Points

  • Gastrointestinal tumors show poor responses to immunotherapy due to complex immune evasion mechanisms.
  • Immunosuppressive cells like regulatory T cells and M2-polarized macrophages hinder T-cell infiltration.
  • Recent advances in transcriptomic technologies aid in understanding mechanisms of immunotherapy resistance.
  • Emerging strategies like combination immunotherapies and mRNA vaccines aim to overcome therapeutic failure.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479c399https://doi.org/10.3389/fimmu.2025.1641518
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