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July 31, 2025PharmaceuticsOpen Access

Leveraging the Tumor Microenvironment as a Target for Cancer Therapeutics: A Review of Emerging Opportunities

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Authors

HGHakan GüvenZSZoltán Székely

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Overview

Review highlights how tumor microenvironment influences cancer therapeutics, suggesting novel strategies for targeting specific parameters.

Key Points

  • MAIN FINDING: The tumor microenvironment presents unique challenges and opportunities for cancer therapeutics.
  • KEY EVIDENCE: Significant changes occur in the microenvironment as tumors exceed 1–2 mm3, impacting treatment efficacy.
  • APPROACH: The review examines five key parameters of the tumor microenvironment and their relevance to cancer types.
  • SIGNIFICANCE: Understanding TME dynamics can lead to more effective therapeutic designs and improved cancer treatment outcomes.

Cite This Study

Güven et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf3e6https://doi.org/10.3390/pharmaceutics17080980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The tumor microenvironment: a dynamic ecosystem and therapeutic nexus in modern oncology2026
  2. 2Nanotechnology Meets the Tumor Microenvironment: Unlocking New Horizons in Cancer Therapy2025 · 14 citations
  3. 3Strategies for Effective Cancer Therapy Through Understanding the Tumor Microenvironment2025
  4. 4Soil and Seed: Tumor Microenvironment Nurtures Immunotherapy Resistance and Renewal2025 · 3 citations
  5. 5The Tumor Microenvironment: Impact on Tumor Growth, Metastasis, and Therapeutic Resistance: A Systematic Review2025