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September 10, 2025International Journal of Translational MedicineOpen Access

Current and Future Directions in Immunotherapy for Gastrointestinal Malignancies

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Authors

CLCatherine R. LewisYSYazan SamhouriCSChristopher Sherry

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Overview

This review highlights immunotherapy's potential impact and integration with chemotherapy in gastrointestinal malignancies.

Key Points

  • Current immunotherapy strategies aim to enhance outcomes for gastrointestinal malignancies, a leading cause of cancer death.
  • Integrating immunotherapy with chemotherapy, as seen in colorectal and pancreatic cancers, offers promising therapeutic avenues.
  • Clinical trials are exploring combinations of immunotherapy and chemotherapeutic agents for cholangiocarcinoma and hepatocellular carcinoma.
  • A personalized approach, considering the tumor immune microenvironment, could optimize treatment strategies for GI cancers.

Cite This Study

Lewis et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479c830https://doi.org/10.3390/ijtm5030033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms, advances, and challenges of immunotherapy in gastric cancer2025
  2. 2Current trends on immunotherapy for oncology2025 · 2 citations
  3. 3Emerging IO checkpoints in gastrointestinal oncology2025 · 4 citations
  4. 4Emerging Strategies for Targeting Angiogenesis and the Tumor Microenvironment in Gastrointestinal Malignancies: A Comprehensive Review2025 · 5 citations
  5. 5Revisiting the Immunological Landscape of Locoregional Therapies for Gastrointestinal Cancers: A Shift Toward Interventional Immuno-Oncology2026