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September 18, 2025Blood ScienceOpen Access

Single-cell profiling of long non-coding RNAs in the hematopoietic system

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Authors

YZYu ZhangQHQiuju HuangYZYawen Zhang

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Overview

This research uncovers lncRNA expression in hematopoietic cells, suggesting their role in leukemogenesis and immune regulation.

Key Points

  • Identified 3,463 lineage-specific lncRNAs critical for hematopoiesis across various cell types, including HSPCs.
  • Developed a single-cell lncRNA atlas from 207,113 cells, enhancing understanding of lncRNA functions in normal and leukaemic states.
  • The study shows lncRNA associations with immune response and oxygen regulation in pediatric leukemia cases.
  • Generated insights into lncRNA landscapes may aid in identifying therapeutic targets for leukemia treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d43c79713b0b5dfea7be71https://doi.org/10.1097/bs9.0000000000000240
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