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August 1, 2025International Journal of Oral ScienceOpen Access

Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy

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Authors

JLJingjing LuoTSTongxu SunZLZhenghui Liu

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Overview

Review reveals therapy-induced senescence complicates tumor microenvironment, suggesting new treatment strategies for head and neck cancer.

Key Points

  • MAIN FINDING: Persistent therapy-induced senescent cells hinder long-term treatment efficacy in head and neck cancer.
  • KEY EVIDENCE: These cells contribute to therapy resistance by modifying the tumor microenvironment and promoting immune evasion.
  • APPROACH: The review summarizes the characteristics of therapy-induced senescent cells and their role in cancer progression.
  • SIGNIFICANCE: Understanding these interactions can guide the development of effective senescence-targeting strategies for improved cancer treatment.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd75https://doi.org/10.1038/s41368-025-00380-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapy-Induced Cellular Senescence in Non-Hodgkin Lymphomas, with Emphasis on Aggressive B-Cell Subtypes: Molecular Mechanisms and Emerging Drug Targets2026
  2. 2The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment2025 · 8 citations
  3. 3Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer2025
  4. 4Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment2025 · 14 citations
  5. 5Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics2025