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September 10, 2025TheranosticsOpen Access

The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

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Authors

HSHuanjun ShiMXMingming XiaoYLYangyi Li

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Overview

This review highlights the role of cellular senescence and SASP in the tumor microenvironment, suggesting implications for immunotherapy.

Key Points

  • Cellular senescence impacts the tumor microenvironment and may promote tumor progression through dysfunctional immune cells.
  • Senescent CD8+ and CD4+ T cells show impaired immunosuppression and resistance to immunotherapy, complicating treatment outcomes.
  • Research explores strategies targeting senescence, including clearing senescent cells and inhibiting the tumor-promoting SASP.
  • While promising approaches exist, none are in clinical practice yet, highlighting the need for ongoing research.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479d73ehttps://doi.org/10.7150/thno.112633
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