September 11, 2025Cancer MedicineOpen Access

Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment

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Discussion

Review reveals how cellular senescence and immunosenescence shape melanoma progression, suggesting strategies to improve outcomes.

Cellular senescence and immunosenescence significantly contribute to melanoma's resistance to immune checkpoint inhibitors.
The senescence-associated secretory phenotype alters immune cell behavior, leading to a pro-inflammatory and immunosuppressive tumor microenvironment.
Interventions targeting senescence-related pathways may restore immune function, improving responses in melanoma therapy.
A systematic review of studies highlights the intricate relationship between aging processes and melanoma progression, necessitating further clinical exploration.

Xiong et al. (2025) studied this question.

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