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August 15, 2025Open Access

Epigenetic Shifts Reveal Alzheimer’s Origins after Sustained Picomolar Aβ Exposure

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Authors

APAndrea PaquolaEAErica AcquaroneASAgnieszka Staniszewski

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Overview

Analysis shows epigenetic changes in gene expression influence memory decline in mice with prolonged Aβ exposure, indicating pathways to Alzheimer's disease.

Key Points

  • Sustained exposure to low levels of amyloid-beta leads to memory decline and molecular changes in the brain.
  • DNA methylation and gene expression were profiled in C57B16 mice after prolonged amyloid-beta exposure, revealing key gene alterations.
  • Research observed three phases: memory enhancement, a transitional state, and memory decline in response to amyloid-beta exposure.
  • These findings highlight potential early drivers of Alzheimer's disease pathogenesis, warranting further investigation.

Cite This Study

Paquola et al. (2025) studied this question.

synapsesocial.com/papers/68af75147567bf4f94fee127https://doi.org/10.1101/2025.08.12.668749
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Also Consider

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  1. 1Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology2025
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  4. 4In vivo evidence for soluble Aβ oligomer-driven neuronal metabolic dysfunction in 5xFAD mice2026
  5. 5Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment2025