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October 3, 2025Frontiers in Aging NeuroscienceOpen Access

Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue

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Authors

ADAshley H. DucheOTOliver TanABAndrius Baskys

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Overview

Differential gene expression analysis identifies biomarkers linked to AD, suggesting potential drug repurposing options.

Key Points

  • Gene expression signatures effectively distinguished AD activity in post-mortem brain tissue samples.
  • The analysis revealed upregulation of extracellular matrix processes and downregulation of hormonal pathways in AD-affected regions.
  • Key factors influencing AD progression include the APOE genotype and sex differences among participants.
  • Promising drug repurposing candidates such as FGFR inhibitors were identified, highlighting potential new therapeutic approaches.

Cite This Study

Duche et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b345fhttps://doi.org/10.3389/fnagi.2025.1591946
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