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July 26, 2025Korean Journal of GastroenterologyOpen Access

Expanding Role of Gastroenterologists in Acute Gastrointestinal Graft-versus-Host Disease: From Diagnosis and Management to Microbiome-Based Strategies

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Authors

SLSeung Bum Lee

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Overview

Gastroenterologists improve outcomes in acute gvhd management, emphasizing microbiome approaches and personalized care.

Key Points

  • Gastroenterologists are crucial for diagnosing and managing acute graft-versus-host disease in transplant patients.
  • Ruxolitinib is the standard second-line therapy for steroid-refractory gvhd, while vedolizumab shows promise for gut health.
  • Reduced microbiome diversity correlates with increased severity and mortality in acute gvhd cases.
  • Fecal microbiota transplantation may help some patients with steroid-refractory gvhd, but evidence is currently limited.

Cite This Study

Seung Bum Lee (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce54ehttps://doi.org/10.4166/kjg.2025.049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  2. 2Biochemical markers and emerging therapies for intestinal manifestation of graft-versus-host disease2025 · 2 citations
  3. 3“The microbiome in graft-versus-host disease: a tale of two ecosystems”2025 · 28 citations
  4. 4The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut2025
  5. 5[Therapeutic strategies for graft-versus-host disease in the new era].2025