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July 16, 2025International Journal of Molecular SciencesOpen Access

Metabolic Disturbances Involved in Cardiovascular Diseases: The Role of Mitochondrial Dysfunction, Altered Bioenergetics and Oxidative Stress

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Authors

DPDonatella PietrangeloCLCaroline LopaMLMargherita Litterio

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Overview

This review highlights mitochondrial dysfunction and oxidative stress as key factors in cardiovascular diseases, suggesting new therapeutic strategies for improvement.

Key Points

  • Mitochondrial dysfunction is a hallmark of cardiovascular diseases due to its role in ATP production.
  • Oxidative stress and impaired bioenergetics contribute to heart failure and vascular damage in hypertension.
  • The study discusses emerging therapies targeting metabolic modulators for better heart health.
  • Recent research emphasizes the importance of cellular metabolism in understanding chronic and acute cardiovascular conditions.

Cite This Study

Pietrangelo et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8cc9cchttps://doi.org/10.3390/ijms26146791
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  1. 1Oxidative Stress and Mitochondrial Dysfunction in Cardiovascular Aging: Current Insights and Therapeutic Advances2026
  2. 2Mitochondrial Transport Proteins in Cardiovascular Diseases: Metabolic Gatekeepers, Pathogenic Mediators and Therapeutic Targets2025
  3. 3Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target2025
  4. 4Mitochondrial‑endoplasmic reticulum crosstalk: Molecular mechanisms and implications for cardiovascular disease (Review)2025 · 8 citations
  5. 5Mitochondrial metabolic reprogramming in diabetic cardiomyopathy2026 · 1 citations