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July 30, 2025Molecular Medicine Reports

Mitochondrial‑endoplasmic reticulum crosstalk: Molecular mechanisms and implications for cardiovascular disease (Review)

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Authors

YLYue LiuXGXuejia GongSXShasha Xing

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Overview

Review explores mitochondrial-endoplasmic reticulum crosstalk's impact on cardiovascular disease, highlighting its therapeutic potential.

Key Points

  • Mitochondrial and endoplasmic reticulum dysfunction are linked to cardiovascular disease, particularly in younger populations.
  • The interaction of mitochondria-associated ER membrane is crucial for maintaining cellular homeostasis related to CVD.
  • Key mechanisms involve regulating lipid transport and calcium homeostasis, influencing cell survival and death.
  • Research suggests targeting MAM could offer new therapeutic strategies for managing cardiovascular diseases.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cef52https://doi.org/10.3892/mmr.2025.13640
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