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September 23, 2025AntioxidantsOpen Access

Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target

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Authors

MXMi XiangMYMengling YangLZLijuan Zhang

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Implication

Review highlights mitochondrial dna roles and preclinical strategies for cardiovascular diseases, indicating potential therapeutic avenues.

Key Points

  • Mitochondrial dna dysfunction drives a damaging cycle in cardiovascular diseases, leading to tissue injury.
  • Impairments in oxidative phosphorylation elevate reactive oxygen species and contribute to inflammation.
  • Interrupting this cycle through mtDNA repair and immune blockage may advance cardiovascular disease therapies.
  • Clinical strategies must address gaps in translating mitochondrial genome medicine for effective cardiovascular interventions.

Cite This Study

Xiang et al. (2025) studied this question.

synapsesocial.com/papers/68d43d75713b0b5dfea7d53dhttps://doi.org/10.3390/antiox14091138
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