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May 31, 2026Biomedicine & PharmacotherapyOpen Access

The review summarizes mechanisms of mitochondrial metabolic reprogramming in diabetic cardiomyopathy, including altered substrate utilization, impaired oxidative phosphorylation, and disruption of mitochondrial quality control, governed by signaling pathways such as AMPK/PGC-1α, PI3K/Akt/mTOR, HIF-1α, and TGF-β/Smad.

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Population

Diabetic cardiomyopathy

Design

Review

Authors

YZYuting ZhouHTHao TianZXZhongyuan Xia

Discussion

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Overview

Should not change practice in diabetic cardiomyopathy; leaves open validation of pathway-targeted therapies.

Key Points

  • This review aims to summarize the mechanisms of mitochondrial metabolic reprogramming in diabetic cardiomyopathy (DCM) and explore potential therapeutic strategies.
  • Review of contemporary studies on mitochondrial dysregulation in DCM.
  • Analysis of metabolic shifts in cardiomyocytes under diabetic conditions.
  • Discussion of regulatory networks and therapeutic strategies targeting mitochondrial metabolism.
  • Chronic hyperglycemia and insulin resistance lead to altered substrate utilization in cardiomyocytes.
  • Enhanced glycolysis and disrupted fatty acid oxidation contribute to oxidative stress and cellular apoptosis.
  • Potential therapeutic strategies targeting mitochondrial pathways may improve cardiovascular health in DCM.

Structured PICO

P
Population
Diabetic cardiomyopathy

This review provides a comprehensive framework for understanding the pathogenesis of diabetic cardiomyopathy through the lens of mitochondrial metabolic reprogramming and highlights potential precision therapeutic interventions.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a1bcfe15783ba022b6fbcabhttps://doi.org/10.1016/j.biopha.2026.119559
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging2025 · 12 citations
  2. 2Gut Microbiota‐Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers2025
  3. 3Recent advances in mitochondrial fission and fusion in diabetic cardiomyopathy2026
  4. 4Diabetic cardiomyopathy: Target immune cell from mechanism to treatment2026
  5. 5Metabolic Modulation of Pyruvate Dehydrogenase and Glucose Oxidationin Diabetic Cardiomyopathy: Pathways, Perspectives, and Potentials.2025