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August 6, 2025BMC NephrologyOpen Access

Severe renal haemosiderosis in a patient with untreated paroxysmal nocturnal haemoglobinuria: a case report

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Authors

ZGZhong Zhen GohKTKenny TangKCKatrina Chau

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Overview

Case report reveals acute kidney injury and renal haemosiderosis in a woman with untreated PNH, indicating critical need for monitoring.

Key Points

  • MAIN FINDING: Severe renal haemosiderosis developed in a patient with untreated paroxysmal nocturnal haemoglobinuria.
  • KEY EVIDENCE: Renal biopsy showed extensive haemosiderin deposits and acute tubular injury associated with chronic haemolysis.
  • APPROACH: The patient, a 74-year-old woman, had a history of aplastic anaemia, with diagnostics including blood flow cytometry and renal biopsy.
  • SIGNIFICANCE: Early detection and intervention for paroxysmal nocturnal haemoglobinuria are crucial to prevent severe renal complications.

Cite This Study

Goh et al. (2025) studied this question.

synapsesocial.com/papers/689521e49f4f1c896c4282eehttps://doi.org/10.1186/s12882-025-04343-5
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Also Consider

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  1. 1Paroxysmal nocturnal hemoglobinuria masquerading as hemolytic uremic syndrome: a Case Report2025
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  4. 4A diagnostic pivot: Paroxysmal nocturnal hemoglobinuria mimicking refractory immune thrombocytopenia in an elderly woman with autoimmune comorbidities2025
  5. 5Paroxysmal nocturnal hemoglobinuria with large clones in non-hypoplastic myelodysplastic syndrome- report of two cases2025 · 1 citations