PO60 | Asymptomatic PNH clone in acquired aplasia (AA)

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Case report describes silent PNH clone in a patient with anemia and acquired aplasia, indicating monitoring is essential.

MAIN FINDING: A 62-year-old man diagnosed with acquired aplasia also had a silent PNH clone present.
KEY EVIDENCE: Laboratory results showed significant anemia (hemoglobin 8.1 g/dL) and thrombocytopenia (platelets 9.0 x103/uL).
APPROACH: Diagnosis was based on bone marrow aspirate indicating hypocellularity and flow cytometry revealing 3% PNH granulocytes.
SIGNIFICANCE: Monitoring subclinical PNH clones in AA patients is crucial as they may progress to classical PNH.

A 2025 study studied this question.

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Case report describes silent PNH clone in a patient with anemia and acquired aplasia, indicating monitoring is essential.

MAIN FINDING: A 62-year-old man diagnosed with acquired aplasia also had a silent PNH clone present.
KEY EVIDENCE: Laboratory results showed significant anemia (hemoglobin 8.1 g/dL) and thrombocytopenia (platelets 9.0 x103/uL).
APPROACH: Diagnosis was based on bone marrow aspirate indicating hypocellularity and flow cytometry revealing 3% PNH granulocytes.
SIGNIFICANCE: Monitoring subclinical PNH clones in AA patients is crucial as they may progress to classical PNH.

A 2025 study studied this question.

View Full Paper

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