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September 10, 2025Frontiers in MedicineOpen Access

Paroxysmal nocturnal hemoglobinuria masquerading as hemolytic uremic syndrome: a Case Report

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Authors

MGMenghan GaoBLBo LiuYJYao Jian-ping

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Overview

Case report reveals PNH mimicking hemolytic uremic syndrome in a patient, emphasizing diagnostic challenges.

Key Points

  • Misdiagnosis of paroxysmal nocturnal hemoglobinuria as hemolytic uremic syndrome delayed proper treatment.
  • The patient's initial symptoms included fever, diarrhea, and acute renal failure, complicating the diagnosis.
  • Diagnosis was confirmed through renal biopsy, showcasing the importance of timely and accurate diagnostic tests.
  • Intravascular hemolysis is common in both PNH and hemolytic uremic syndrome, challenging differentiation.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791c75https://doi.org/10.3389/fmed.2025.1553168
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Also Consider

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  1. 1Paroxysmal Nocturnal Hemoglobinuria: Unraveling Its Molecular Pathogenesis and Advancing Targeted Therapeutic Strategies2025
  2. 2Paroxysmal Nocturnal Hemoglobinuria: Unraveling Its Molecular Pathogenesis and Advancing Targeted Therapeutic Strategies2025 · 5 citations
  3. 3Severe renal haemosiderosis in a patient with untreated paroxysmal nocturnal haemoglobinuria: a case report2025
  4. 4Diagnostic delays and misdiagnosis patterns in paroxysmal nocturnal hemoglobinuria2025
  5. 5A diagnostic pivot: Paroxysmal nocturnal hemoglobinuria mimicking refractory immune thrombocytopenia in an elderly woman with autoimmune comorbidities2025