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August 7, 2025International Journal of Colorectal DiseaseOpen Access

β-Sitosterol improves murine ulcerative colitis by inhibiting the expression of ribosomal proteins and the attempted polarization of type 1 macrophages

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Authors

RGRui GengYCYongqing CaoTLTe Liu

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Overview

Experimental research shows β-sitosterol improved inflammation and immune response in ulcerative colitis mice, suggesting therapeutic potential.

Key Points

  • β-Sitosterol treatment significantly reduced intestinal damage and inflammation in ulcerative colitis mice models.
  • Single-cell RNA-sequencing revealed decreased immune cell subpopulations and macrophage numbers following treatment.
  • Histopathological and flow cytometry analyses confirmed reductions in inflammatory factors like IL-1β and iNOS.
  • The findings highlight β-sitosterol's role in suppressing macrophage polarization and signaling pathways, offering insights into UC therapies.

Cite This Study

Geng et al. (2025) studied this question.

synapsesocial.com/papers/689521e49f4f1c896c4280efhttps://doi.org/10.1007/s00384-025-04974-y
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Also Consider

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  1. 1Molecular Mechanism of Butyrate Modulating Treg/Th17 Balance in UC Through cAMP-PKA/mTOR Axis2025
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  3. 3Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function2025
  4. 4α-Bisabolol, a Dietary Bioactive Terpene Attenuates Oxidative Stress and Inflammation in Colonic Mucosa of Acetic Acid-Induced Colitis in Rats2025
  5. 5Isoimperatorin, a natural furanocoumarin, ameliorates ulcerative colitis by inducing Treg cell generation and promoting mucosal healing2025