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August 7, 2025Molecular MedicineOpen Access

Isoimperatorin, a natural furanocoumarin, ameliorates ulcerative colitis by inducing Treg cell generation and promoting mucosal healing

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Authors

YFYulai FangSMSeung‐Kee MinHCHongxin Chen

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Overview

Oral isoimperatorin reduced ulcerative colitis symptoms in mice, suggesting Treg cell generation is crucial for mucosal repair.

Key Points

  • Isoimperatorin significantly improved disease symptoms in mice with ulcerative colitis using 20 and 40 mg/kg doses.
  • The compound elevated Treg cell percentage while not affecting Th17 cells in mesenteric lymph node tissues.
  • Isoimperatorin enhanced expression of proteins involved in mucosal healing and intestinal barrier integrity.
  • Depleting Treg cells reduced isoimperatorin's effectiveness in repairing the intestinal barrier and alleviating UC symptoms.

Cite This Study

Fang et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13ba42https://doi.org/10.1186/s10020-025-01334-y
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