Molecular Mechanism of Butyrate Modulating Treg/Th17 Balance in UC Through cAMP-PKA/mTOR Axis

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Mouse model shows butyrate alters Treg/Th17 balance in ulcerative colitis, suggesting new treatments.

Butyrate treatment significantly reduced disease activity index (DAI) and spleen index (SI) in UC mice.
High doses of butyrate improved recovery, reversing weight loss and pathological changes in DSS-induced UC.
Assessment techniques included RT-qPCR and flow cytometry to analyze immune cell subsets and signaling pathways.
The cAMP-PKA/mTOR pathway is crucial for butyrate's role in restoring immune balance in ulcerative colitis.

Li et al. (2025) studied this question.

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