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September 8, 2026International Journal of Molecular SciencesOpen Access

Dystroglycan signaling emerges as a key factor in cardiac remodeling and fibrosis in acquired HFrEF.

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Design

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Key result

Dystroglycan signaling, essential for sarcolemma stability, is emerging as a key factor in cardiac remodeling and fibrosis in acquired heart failure with reduced ejection fraction.

Authors

BPBhola Shankar PradhanMMMichał Ma̧czewski

Discussion

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Overview

Dystroglycan modulation should not yet inform HFrEF care; extends its role from inherited dystrophies but remains hypothesis-generating.

Key Points

  • To review the signaling mechanisms of dystroglycan in cardiac muscle and evaluate its emerging roles in cardiac remodeling, fibrosis, and acquired heart failure with reduced ejection fraction.
  • Narrative synthesis of cellular and molecular literature regarding dystrophin–glycoprotein complex function in healthy myocardium versus diseased states.
  • Comparative analysis of dystroglycan pathway signaling in inherited muscle dystrophies and acquired heart failure.
  • Dystroglycan maintains cardiomyocyte sarcolemmal integrity, mediates mechanotransduction, coordinates force transmission, and regulates intracellular calcium handling.
  • Perturbations and structural remodeling of dystroglycan complexes are linked to cardiomyocyte death, adverse ventricular remodeling, and progressive myocardial fibrosis in heart failure with reduced ejection fraction.

PICO

P
Population
Heart failure with reduced ejection fraction (HFrEF)
E
Exposure / Comparator
Dystroglycan signaling

Dystroglycan remodeling may play a significant role in the pathophysiology of acquired HFrEF, extending its known importance beyond inherited muscular dystrophies.

Cite This Study

Pradhan et al. (2026) conducted a review in Heart failure with reduced ejection fraction (HFrEF). Dystroglycan signaling was evaluated. Dystroglycan signaling, essential for sarcolemma stability, is emerging as a key factor in cardiac remodeling and fibrosis in acquired heart failure with reduced ejection fraction.

synapsesocial.com/papers/6a9fd79b58e84d0ff5b466bfhttps://doi.org/10.3390/ijms27177948
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