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August 16, 2025International Journal of Molecular SciencesOpen Access

Analysis of Beta-Dystroglycan in Different Cell Models of Senescence

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Authors

GJGuadalupe Elizabeth Jiménez-GutiérrezTZTania Ivette Zavaleta-VásquezJLJessica Alexandra Lizcano-Meneses

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Overview

This analysis finds altered beta-dystroglycan localization in senescent fibroblasts, suggesting roles in cellular aging.

Key Points

  • Beta-dystroglycan shows altered localization in senescent cells, indicating a potential role in aging.
  • In aged fibroblasts, increased levels of the intracellular domain of beta-dystroglycan were observed, but not in other models.
  • Analysis involved chronologically aged, sodium butyrate-induced, and Hutchinson–Gilford progeria syndrome fibroblasts.
  • Alterations in beta-dystroglycan could inform future research on its role in senescence and aging.

Cite This Study

Jiménez-Gutiérrez et al. (2025) studied this question.

synapsesocial.com/papers/68c235fdb210217d64772944https://doi.org/10.3390/ijms26167726
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