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October 5, 2025Open Access

Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction

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Authors

MLMaicon Landim-VieiraVJVivek JaniESEmily Shiel

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Overview

Observational analysis shows cardiac dysfunction in Dsg2-mutant mice, highlighting the role of DSG2 in mechanotransduction.

Key Points

  • Loss of desmoglein-2 leads to age-dependent cardiac dysfunction and Z-disc structural defects.
  • In adolescent Dsg2-mutant mice, calcium-activated force was reduced in left ventricle muscle bundles but preserved in isolated cardiomyocytes.
  • Desmoglein-2 is crucial for mechanical coupling between cardiomyocytes, affecting contractile integrity.
  • This research reveals a novel role for desmoglein-2 at both cellular and tissue levels in cardiac function.

Cite This Study

Landim-Vieira et al. (2025) studied this question.

synapsesocial.com/papers/68e25559d6d66a53c247531bhttps://doi.org/10.1101/2025.10.03.680335
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