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September 5, 2026EP EuropaceOpen Access

Bleeding-Related Conditions, Procedural Safety, and Mortality After Left Atrial Appendage Closure

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Key result

Left atrial appendage closure is associated with varying rates of bleeding-related conditions, procedural safety events, and mortality.

Authors

GMGrégoire MassoulliéCFCome FleuryETEmeline Tourret

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Overview

Baseline bleeding conditions warrant caution in LAA closure candidates; leaves open whether mitigation alters mortality.

Key Points

  • Evaluate the association between baseline bleeding-related conditions, procedural complications, and long-term mortality in patients undergoing left atrial appendage closure.
  • Analyzed clinical safety outcomes, procedural success, and post-intervention adverse events in patients treated with left atrial appendage closure.
  • Assessed the prognostic impact of pre-existing bleeding conditions on subsequent mortality and vascular complications.
  • Procedural safety profiles demonstrate feasibility, though baseline bleeding vulnerability influences perioperative risk.
  • Pre-existing bleeding-related conditions are linked to variations in post-procedural adverse events and long-term overall mortality.

Cite This Study

Massoullié et al. (2026) studied this question. Left atrial appendage closure is associated with varying rates of bleeding-related conditions, procedural safety events, and mortality.

synapsesocial.com/papers/6a9bd4126b95aff0620eb790https://doi.org/10.1093/europace/euag235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Major complications and unplanned cardiac surgery during left atrial appendage closure: A nationwide cohort study2026
  2. 2Left atrial appendage closure in patients with hereditary hemorrhagic telangiectasia and atrial fibrillation: a prospective study and systematic review2026
  3. 3Concomitant left atrial appendage exclusion during cardiac surgery: a single-center case series on technique profile, residual flow, and early safety2026
  4. 4Percutaneous Left Atrial Appendage Closure for Thromboembolic Prevention in Atrial Fibrillation2025
  5. 5Clinical practice in left atrial appendage closure with focus on antithrombotic therapy: results from a European Heart Rhythm Association survey2026