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July 26, 2026BiomedicinesOpen Access

Mechanisms of Hypertension in Women: Interactions Between Vascular Ageing, Metabolic Dysfunction, and Hormonal Regulation

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Authors

SHShiva HooshmandiNFNicholas S. FreestoneFAFrancesca Arrigoni

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Overview

Narrative review uncovers factors influencing hypertension in women, suggesting new avenues for cardiovascular risk management.

Key Points

  • This review aims to summarize the mechanisms by which vascular ageing, hormonal changes, and metabolic dysfunction affect hypertension in women.
  • Conducted a narrative review using PubMed, Scopus, and Google Scholar.
  • Synthesized clinical, epidemiological, and mechanistic studies on hypertension in women.
  • Excluded studies without defined menopausal status or documented reproductive milestones.
  • Menopause and vascular ageing significantly impact endothelial function and vascular resistance.
  • Chronic inflammation and genetic factors contribute to higher cardiovascular risk in women.
  • Emerging therapies like GLP-1 receptor agonists may enhance cardiovascular risk management in women.

Cite This Study

Hooshmandi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd793bahttps://doi.org/10.3390/biomedicines14081667
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Also Consider

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  1. 1POST MENOPAUSAL HYPERTENSION – PATHOPHYSIOLOGY, MOLECULAR MECHANISM, THERAPEUTIC STRATEGIES AND NEWER APPROACHES2026
  2. 2Sex-Biased Pharmacotherapeutic Disparities in Hypertension2026
  3. 3Autonomic mechanisms of blood pressure control in females across the lifespan2025
  4. 4CLINICAL FEATURES AND EARLY PREVENTION APPROACHES FOR ARTERIAL HYPERTENSION IN WOMEN OF REPRODUCTIVE AGE: THE ROLE OF ENDOTHELIN-1 AND AMBULATORY BLOOD PRESSURE MONITORING2025
  5. 5Phenotypes of Hypertension: Impact of Age and Sex on Hemodynamic Mechanisms2025