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July 24, 2026Medical SciencesOpen Access

Metabolic Effects of Testosterone Replacement Therapy in Men with Functional Secondary Hypogonadism, Obesity and Type 2 Diabetes or Metabolic Syndrome: A Systematic Review

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Authors

CNChristos NtaisAVApostolos VantarakisICIoanna P. Chatziprodromidou

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Overview

Systematic review demonstrates potential metabolic benefits of TRT in obese men with functional secondary hypogonadism, indicating further investigation is needed.

Key Points

  • This review aims to assess the metabolic effects of testosterone replacement therapy in men with functional secondary hypogonadism, obesity, and metabolic disorders.
  • Conducted a systematic review of double-blind randomized placebo-controlled trials.
  • Included studies with adult men suffering from biochemical hypogonadism and metabolic conditions.
  • Assessed risk of bias and evidence certainty using the Cochrane RoB 2 framework and GRADE.
  • Improved body composition was noted, particularly increased lean mass and reduced fat mass.
  • Favorable effects on insulin resistance were observed, but results were inconsistent across trials.
  • Low-certainty evidence was found for metabolic outcomes such as fat mass, lean mass, and insulin resistance metrics.

Cite This Study

Ntais et al. (2026) studied this question.

synapsesocial.com/papers/6a63008d395161722cd15664https://doi.org/10.3390/medsci14030418
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Benefits of Testosterone Replacement Therapy in Men: Evidence from A Narrative Review2025 · 2 citations
  2. 2Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism2025
  3. 3Dietary Interventions and Testosterone Levels in Obese Men: A Systematic Review Comparing the Mediterranean Diet, Ketogenic Diet, and Intermittent Fasting2026
  4. 4Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men2025
  5. 5Evaluation of serum LH and its role in hypogonadism among men with type 2 Diabetes Mellitus2024