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October 3, 2025Cardiovascular DiabetologyOpen Access

Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism

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Authors

FBFabrice BonnetPVPatricia VaduvaJHJean‐Michel Halimi

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Overview

Observational analysis shows reduced acute kidney injury and cardiovascular events in men with diabetes and hypogonadism, suggesting benefits of testosterone therapy.

Key Points

  • Testosterone therapy significantly reduces the risk of acute kidney injury in diabetic men, indicating potential renal protective effects.
  • In a cohort of 26,027 men, testosterone treatment was linked to a 19% lower risk of kidney failure requiring replacement therapy.
  • Patients receiving testosterone therapy experienced fewer cardiovascular events, including a 15% reduction in myocardial infarction risk.
  • These findings underscore the importance of considering testosterone therapy in managing diabetic men with hypogonadism for preventing kidney injury.

Cite This Study

Bonnet et al. (2025) studied this question.

synapsesocial.com/papers/68dfe93cdaa1363beb049d55https://doi.org/10.1186/s12933-025-02930-2
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