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July 26, 2026NutrientsOpen Access

Dietary Interventions and Testosterone Levels in Obese Men: A Systematic Review Comparing the Mediterranean Diet, Ketogenic Diet, and Intermittent Fasting

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Authors

SVSandro La VigneraRCRosita A. Condorelli

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Overview

Systematic review compares testosterone effects of Mediterranean diet, ketogenic diet, and intermittent fasting in obese men, suggesting VLCKD is most effective.

Key Points

  • This review assesses how different dietary interventions affect testosterone levels in obese men with male obesity secondary hypogonadism.
  • Conducted a systematic review following PRISMA 2020 guidelines.
  • Performed comprehensive searches across SciSpace, Google Scholar, and PubMed until June 2026.
  • Included studies focused on adult males (BMI ≥ 30 kg/m²) following Mediterranean diet, ketogenic diet, or intermittent fasting with testosterone assessment.
  • VLCKD showed significant increases in total testosterone levels (+1.5 to +3.0 nmol/L) with strong evidence.
  • Intermittent fasting indicated potential benefits but with more variability in outcomes.
  • Limited evidence for the Mediterranean diet regarding its effects on testosterone, primarily assessing metabolic outcomes.

Cite This Study

Vignera et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd793d4https://doi.org/10.3390/nu18152417
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