Bidirectional Mendelian randomization shows a positive link between mitochondrial dna copy number and renal function measures.
Key Points
A positive association was found between genetically predicted mitochondrial dna copy number and estimated glomerular filtration rate, suggesting potential causal links.
Forward mendelian randomization analysis revealed an odds ratio of 1.007 for the association with eGFR, indicating a small effect size.
Sensitivities in analyses indicated that neutrophil count may influence the association between mtDNA-CN and renal function measures.
Further research is warranted to address confounding factors observed and ensure reliable implications for renal health.