Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 5, 2026Discover OncologyOpen Access

Multi-omics pan-cancer analysis reveals heterogeneous BCAA metabolism and its impact on the tumor immune microenvironment and prognosis

View Full Paper
Ask AI
Bookmark
Share

Authors

JQJinqin QianFWFang WangLZLiqun Zhou

Discussion

Loading...

Member takes

Overview

Multi-omics analysis maps BCAA metabolism's impact on tumor immunity and prognosis across various cancers, indicating treatment implications.

Key Points

  • This research aims to explore the heterogeneity of BCAA metabolism in cancer and its effects on the tumor immune microenvironment.
  • Conducted integrated multi-omics analysis of 33 cancer types from TCGA.
  • Characterized 18 core BCAA metabolic genes using RNA-seq and epigenomic data.
  • Developed cancer-specific prognostic models via LASSO-Cox regression.
  • Extensive heterogeneity in BCAA metabolic gene regulation observed across tumors and normal tissues.
  • High BCAA scores linked to an immunosuppressive TIME with elevated M2 macrophages and reduced CD8 + T cells.
  • Developed robust prognostic signatures for 23 malignancies; high-risk patients showed poorer immunotherapy outcomes.

Cite This Study

Qian et al. (2026) studied this question.

synapsesocial.com/papers/6a49f36ff5d1d45b287ff925https://doi.org/10.1007/s12672-026-05527-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies2025
  2. 2Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies2025
  3. 3Integrative multi-omics analysis of bile acid metabolism as a prognostic determinant in colorectal cancer2026
  4. 4Bile acids impedes tumor-specific T cell responses by modulating organelle-specific stress response 27542025
  5. 5Integrated transcriptomics reveals a TNFRSF-metabolism axis and a context-dependent BCMA signaling state in myeloma progression2026