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July 26, 2025Cancer Biology and MedicineOpen Access

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies

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Authors

ZLZiyou LinCCChang ChangSZShuyu Zhao

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Overview

This review uncovers how amino acids regulate tumor immunity and growth, highlighting therapeutic strategies like CAR-T cell therapy.

Key Points

  • The tumor immune microenvironment (TIME) is shaped by amino acids affecting immune evasion and tumor progression.
  • Key insights reveal how amino acid metabolism influences tumor cell growth and immune cell function within the TIME.
  • Emerging therapeutic strategies, including CAR-T cell therapy, target amino acid metabolism to potentially reprogram the TIME.
  • This comprehensive review highlights future research directions for clinical applications of amino acid-targeted interventions.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce561https://doi.org/10.20892/j.issn.2095-3941.2025.0115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints2025
  2. 2Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities2025 · 11 citations
  3. 3The tumor immune microenvironment: implications for cancer immunotherapy, treatment strategies, and monitoring approaches2025
  4. 4Multi-omics pan-cancer analysis reveals heterogeneous BCAA metabolism and its impact on the tumor immune microenvironment and prognosis2026
  5. 5Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms2025