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June 27, 2026Indian Journal of Pharmacology

Comparison of pharmacokinetics of sitagliptin 100 mg tablets in healthy Asian Indian and Thai volunteers

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Authors

ASAnurag SaroAKArshad H. KhurooSKSudershan Kumar

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Overview

Randomized trial compares pharmacokinetics of sitagliptin in healthy Asian Indian and Thai volunteers, suggesting ethnicity does not affect absorption.

Key Points

  • The aim was to compare the pharmacokinetics of sitagliptin 100 mg in healthy Asian Indian and Thai volunteers.
  • Conducted two independent crossover evaluations in healthy adults of Indian and Thai origin.
  • Participants received a single 100 mg dose of sitagliptin under fasting conditions and were switched to the alternate product after a washout period.
  • Plasma sitagliptin was measured using LC-MS/MS and analyzed using non-compartmental analysis.
  • Cmax, AUC 0–t, and AUC 0–∞ for both ethnic groups fell within the 80%–125% bioequivalence interval.
  • No significant differences were detected between the test and reference formulations across both populations.
  • Both formulations were well tolerated, indicating successful bioequivalence.

Cite This Study

Saro et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f3e3https://doi.org/10.4103/ijp.ijp_44_26
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