Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025European Journal of Drug Metabolism and PharmacokineticsOpen Access

Bioequivalence and Pharmacokinetic Evaluation of Two Metformin Hydrochloride Tablets Under Fasting and Fed Conditions in Healthy Chinese Volunteers

View Full Paper
Ask AI
Bookmark
Share

Authors

YHYuxing HuangEast China Normal UniversityQCQiu-han CaiTianjin University of Traditional Chinese MedicineMLMeifang LiFujian Medical University

Discussion

Loading...

Member takes

Implication

This trial evaluates bioequivalence of metformin hydrochloride under fasting and fed conditions, suggesting accessibility for diabetes treatment.

Key Points

  • The study found that generic metformin is bioequivalent to the reference product under both conditions.
  • Geometric mean ratios (GMRs) under fasting conditions were 103.12% for Cmax and met bioequivalence criteria.
  • In fed conditions, GMRs were 93.98% for Cmax, showing effects of food on pharmacokinetics.
  • Safety profiles were consistent across formulations, indicating that the generic is well tolerated.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4fc0https://doi.org/10.1007/s13318-025-00961-4
View Full Paper
Ask AI
Bookmark
Share