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September 10, 2025MoleculesOpen Access

Development and Validation of a Highly Sensitive LC–MS/MS Method for the Precise Quantification of Sitagliptin in Human Plasma and Its Application to Pharmacokinetic Study

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Authors

YSY. G. SongWSWang-Seob ShimESEunseo Song

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Implication

Innovative LC–MS/MS method quantifies sitagliptin levels in human plasma, suggesting high sensitivity and validation.

Key Points

  • A highly sensitive LC–MS/MS method effectively quantifies sitagliptin in human plasma with minimal sample volume.
  • Validation shows a linear range of 5–1000 ng/mL with a correlation coefficient of r² > 0.998.
  • The developed method utilizes methyl tert-butyl ether for liquid-liquid extraction and achieves rapid results in under 2 minutes.
  • This approach is well-suited for pharmacokinetic studies, ensuring accuracy and reliability in bioequivalence assessments.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d647929abhttps://doi.org/10.3390/molecules30142995
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