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June 20, 2026Blood AdvancesOpen Access

Outcomes of Adolescents and Young Adults with AML Treated on Pediatric vs Adult Protocols

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Authors

BKBaher KrayemJBJeetayu BiswasADAndriy Derkach

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Overview

Retrospective study examines survival outcomes in adolescents and young adults with AML treated under pediatric and adult protocols, suggesting adult regimens may offer better survival rates.

Key Points

  • This study aims to compare treatment outcomes of adolescents and young adults with AML on pediatric versus adult protocols.
  • Single-center retrospective study of 81 AYA patients aged 14-29 with newly diagnosed AML
  • Patients analyzed based on treating service and induction regimens
  • Treatment included pediatric ADE-based induction and adult 7+3 induction followed by consolidation.
  • Five-year overall survival was better for adult-service patients (77.9%) than for pediatric patients (56.7%)
  • Complete response rates were similar between groups (79% adult vs 78% pediatric)
  • ELN 2022 risk category remained an independent prognostic factor, while treatment protocol did not.

Cite This Study

Krayem et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a536ee1https://doi.org/10.1182/bloodadvances.2026020372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of adolescent and young adult patients with AML treated on adult versus pediatric protocols2025
  2. 2Overall survival in patients with acute lymphoblastic leukemia in the aya population, treated with modified pediatric chemotherapeutic schemes, a real-life study2025
  3. 3T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults2025 · 2 citations
  4. 4Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025
  5. 5Continuity of paediatric care for adolescents and young adults with leukaemia: a single-centre experience from China2025