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December 8, 2025BloodOpen Access

Outcomes of adolescent and young adult patients with AML treated on adult versus pediatric protocols

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Authors

JMJohn J. Molina

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Overview

Retrospective analysis shows no significant survival difference in AML outcomes for adolescents treated with pediatric or adult regimens, suggesting regimen choice may impact clinical decisions.

Key Points

  • Overall survival did not significantly differ between adult and pediatric regimens for AYA patients with AML, indicating treatment paradigms may not affect outcomes.
  • 94% of AYA patients treated with pediatric protocols received two induction cycles, compared to 16.5% for the adult cohort, highlighting regimen differences in treatment.
  • Observational analysis across single-center data of AYA AML patients identified 138 speciments aged 15-39 years treated from 2016 to 2024 comparing outcomes of adult vs pediatric regimens.
  • This study indicates a need for prospective trials to clarify treatment pathways for optimizing care of AYA patients with AML.

Cite This Study

John J. Molina (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7f6https://doi.org/10.1182/blood-2025-2832
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