Why the study?
Does hemodynamic adaptation to exercise differ between obstructive and non-obstructive hypertrophic cardiomyopathy patients?
Population
25 patients with hypertrophic cardiomyopathy, subdivided into non-obstructive HCM and obstructive HCM.
Comparison
Supine left and right heart catheterization at… vs Non-obstructive HCM vs Obstructive HCM
Design
Cohort
Key result
During exercise, non-obstructive hypertrophic cardiomyopathy patients showed a steeper increase in pulmonary artery wedge pressure than those with obstructive disease (23±3 vs 14±3 mmHg; p<0.05).
Authors
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May guide phenotype-specific dyspnea evaluation in HCM; leaves open targeted interventions pending larger studies.
Cross-Sectional (n=25)
Does hemodynamic adaptation to exercise differ between obstructive and non-obstructive hypertrophic cardiomyopathy patients?
Absolute Event Rate: 23% vs 14%
p-value: p=<0.05
Non-obstructive HCM patients display a steeper increase in left atrial pressure during exercise compared to obstructive HCM patients, suggesting more advanced left atrial myopathy, while LVOTO may paradoxically reduce during supine exercise in overt HOCM.
Baratto et al. (2026) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=25). Non-obstructive hypertrophic cardiomyopathy vs. Obstructive hypertrophic cardiomyopathy was evaluated on Increase in pulmonary artery wedge pressure (PAWP) during exercise (p=<0.05). During exercise, non-obstructive hypertrophic cardiomyopathy patients showed a steeper increase in pulmonary artery wedge pressure than those with obstructive disease (23±3 vs 14±3 mmHg; p<0.05).
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