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December 4, 2025Heart

Exercise training in hypertrophic cardiomyopathy: a meta-analysis of randomised trials with trial sequential analysis

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Meta-analysis shows exercise training enhances peak oxygen consumption in hypertrophic cardiomyopathy, indicating safety and functional benefits.

Exercise training improved peak oxygen consumption by 1.81 mL/kg/min in a total of 290 patients with hypertrophic cardiomyopathy.
The analysis showed no increase in adverse events like arrhythmias or sudden cardiac death during exercise interventions.
Random-effects meta-analysis and trial sequential analysis were utilized to assess intervention efficacy and robustness of evidence.
Further multicentre randomized controlled trials are needed to confirm findings, especially in higher-risk hypertrophic cardiomyopathy patients.

Ribeiro et al. (2025) studied this question.

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Meta-analysis shows exercise training enhances peak oxygen consumption in hypertrophic cardiomyopathy, indicating safety and functional benefits.