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September 5, 2025European Heart Journal - Cardiovascular ImagingOpen Access

Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis

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Authors

KWKarina Wierzbowska‐DrabikEPEszter Dalma PálinkásMDMaria Grazia D’Alfonso

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Overview

Assessment shows hypercontractile phenotype indicates poorer hemodynamics and survival in HCM patients, highlighting urgent clinical implications.

Key Points

  • The hypercontractile phenotype is linked to unfavorable hemodynamics and higher risk of all-cause death.
  • Patients with hypercontractile phenotype had a hazard ratio of 1.44 for all-cause mortality after long-term follow-up.
  • Higher heart rate and lower stroke volume were observed in hypercontractile patients compared to non-hypercontractile.
  • The study involved 1533 hypertrophic cardiomyopathy patients referred for echocardiography across 27 laboratories.

Cite This Study

Wierzbowska‐Drabik et al. (2025) studied this question.

synapsesocial.com/papers/68c23965b210217d6477b1cchttps://doi.org/10.1093/ehjci/jeaf238
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