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June 14, 2026The American Surgeon

Different Surgical Strategies in Colorectal Cancer Patients With Synchronous Liver Metastasis: A Meta-Analysis

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Authors

HBHaitham M. Azmy BasiounyASAli A. ShafikAAA AHMED

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Overview

Meta-analysis evaluates liver-first, colon-first, and simultaneous resection strategies in colorectal cancer with liver metastasis, suggesting no survival advantage for any approach.

Key Points

  • This meta-analysis evaluates the outcomes of different surgical strategies in colorectal cancer patients with synchronous liver metastases.
  • Systematic review of literature across multiple databases including PubMed and Cochrane.
  • Data extraction and analysis performed using Review Manager software.
  • Comparison of three surgical approaches: colon-first, liver-first, and simultaneous resection.
  • Simultaneous resection showed comparable 1-year overall survival rates (90.1% vs 87.9%) to the colon-first approach.
  • No significant differences in 3-year (66.5% vs 56.2%) and 5-year survival rates (48% vs 40.7%) between techniques.
  • Overall, no single surgical strategy provided a clear survival advantage.

Cite This Study

Basiouny et al. (2026) studied this question.

synapsesocial.com/papers/6a2e482cb1cc60ccdea8c7cahttps://doi.org/10.1177/00031348261460472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025
  2. 2Surgical strategy for repeated metastasectomy for advanced colorectal cancer with synchronous liver metastases2025
  3. 3Current status and advances in the treatment of colorectal cancer with liver metastases2025
  4. 4Consideration of tumor genomics in the management of synchronous colorectal liver metastases2025
  5. 5Simultaneous resections of colorectal cancer and synchronous liver metastases: factors associated with textbook outcome and major complications2025