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September 5, 2025Langenbeck s Archives of SurgeryOpen Access

“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”

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Authors

SLSebastian LünseARAnne von RuestenCSConstanze Schneider

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Overview

Retrospective cohort study shows primary tumor resection improves overall survival in colorectal cancer patients with synchronous liver metastases, suggesting tailored treatments.

Key Points

  • Primary tumor resection before liver resection significantly improves long-term survival in colorectal cancer patients.
  • Five-year overall survival was 68% for prior tumor resection compared to 53% for simultaneous surgery, with an HR of 0.44.
  • The analysis utilized Kaplan-Meier and Cox regression methods to evaluate survival outcomes in 209 patients with liver metastases.
  • Simultaneous resection posed higher mortality risk, particularly for older patients, emphasizing the need for careful surgical planning.

Cite This Study

Lünse et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a393https://doi.org/10.1007/s00423-025-03840-3
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