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September 10, 2025Surgery TodayOpen Access

Surgical strategy for repeated metastasectomy for advanced colorectal cancer with synchronous liver metastases

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Authors

TKTetsuro KawazoeRNRyota NakanishiKAKoji Ando

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Overview

Retrospective analysis identifies outcomes of R0 resection in 135 colorectal cancer patients, suggesting improved survival with repeat surgery.

Key Points

  • Initial R0 resection leads to a median recurrence-free survival of 12.3 months for patients with colorectal cancer.
  • Recurrence developed in 80.6% of patients after R0 resection; those who underwent a repeat R0 resection saw improved overall survival.
  • Significantly, conversion surgery performed in patients initially treated with chemotherapy was linked to the absence of extrahepatic metastases.
  • Individualized treatment strategies for colorectal cancer liver metastases may optimize clinical outcomes, tailored to patient characteristics.

Cite This Study

Kawazoe et al. (2025) studied this question.

synapsesocial.com/papers/68d413f8713b0b5dfea61bf2https://doi.org/10.1007/s00595-025-03125-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study”2025
  2. 2Laparoscopic resection combined with ablation for multiple colorectal liver metastases: a multicentre propensity-matched analysis2025
  3. 3Liver transplantation for colorectal metastasis –selection criteria, outcomes, and management recurrence: a systematic review and meta-analysis2025
  4. 4Treatment outcomes in colorectal cancer patients with synchronous liver metastases2025
  5. 5Benchmarking Oncologic Outcomes of Liver Resection For Colorectal Metastases LiverMetSurvey-based Reference Values For Evaluating Alternative Treatments2025