Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2026Chinese Herbal MedicinesOpen Access

Changyanning Granule alleviates DSS-induced ulcerative colitis in mice by regulating gut microbiota, MAPK pathway and intestinal epithelial barrier

View Full Paper
Ask AI
Bookmark
Share

Authors

ZSZiqi SunMYMingyuan YuanXWXiaoli Wang

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates that Changyanning Granule alleviates ulcerative colitis in mice, highlighting its potential therapeutic effects.

Key Points

  • This study aims to investigate the protective effects of Changyanning Granule on DSS-induced ulcerative colitis in mice and explore its underlying mechanisms.
  • Established a mouse colitis model using 3% DSS.
  • Assessed disease activity index and performed histopathological evaluations.
  • Analyzed gut microbiota and inflammatory markers using various biochemical assays.
  • CYNG treatment significantly decreased the disease activity index (DAI) in DSS-induced colitis mice.
  • Restored intestinal barrier function and reduced colonic inflammation observed.
  • Regulated MAPK pathway by inhibiting p-p38 and p-JNK protein levels.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0561fbhttps://doi.org/10.1016/j.chmed.2026.06.001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chinese Yam Polysaccharide Alleviates DSS-Induced Ulcerative Colitis After Antibiotic Pretreatment2026 · 2 citations
  2. 2Yuyang Decoction Regulates Macrophage Polarization and Repairs the Intestinal Mucosal Barrier via the TLRs/Tollip Signaling Pathway2025 · 1 citations
  3. 3Changji’an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway2025
  4. 4Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function2025 · 4 citations
  5. 5Xiaoyao Pill alleviates ulcerative colitis by inhibiting ferroptosis of enterocytes via activating Nrf2/Gpx4 signaling pathway2025