Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 3, 2025BMC Complementary Medicine and TherapiesOpen Access

Changji’an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

WKWei KeSHSiyu HuangHZHe Zhu

Discussion

Loading...

Member takes

Overview

Animal experiments demonstrate that CJAF alleviates IBS-D symptoms in mice while downregulating NGF and TrkA expression.

Key Points

  • CJAF effectively reduces abdominal pain and diarrhea symptoms in IBS-D mice, indicating its potential in treatment.
  • Key findings include downregulation of mRNA and protein expression of NGF, TrkA, and mast cell markers in colonic tissues.
  • Animal study involved administering CJAF and rifaximin over 7 days to assess effects on behavior and colonic health.
  • Results support the therapeutic properties of CJAF, suggesting it may inhibit mast cell activation linked to IBS-D.

Cite This Study

Ke et al. (2025) studied this question.

synapsesocial.com/papers/68dfe935daa1363beb049c5fhttps://doi.org/10.1186/s12906-025-05095-3
View Full Paper
Ask AI
Bookmark
Share