Experimentally, Xiaoyao Pill shows protective effects on ulcerative colitis in mice by reducing ferroptosis in enterocytes, suggesting antioxidant pathways involvement.
Key Points
To explore the protective effect of Xiaoyao Pill against ulcerative colitis and its underlying mechanism.
Established DSS-induced colitis model in mice.
Administered Xiaoyao Pill at different dosages for 10 days.
Conducted transcriptomic analysis for therapeutic targets.
Verified findings using molecular techniques and cellular assays.
Xiaoyao Pill alleviated DSS-induced colon damage and reduced inflammation.
Increased antioxidant enzyme activities were observed in treated mice.
Mechanistic studies demonstrated inhibition of ferroptosis and activation of Nrf2/Gpx4 pathway.