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This review examines the antimicrobial activity and resistance-modifying effects of Terminalia chebula against key bacterial pathogens.

June 13, 2026Frontiers in PharmacologyOpen Access

Terminalia chebula Retz. As a resistance-modifying botanical drug against priority pathogens: a systematic review

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Authors

KZKamran ZamanIndian Council of Medical Research SRSurthi RavedarIndian Council of Medical Research NRNidhi RIndian Council of Medical Research

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Implication

Systematic review evaluates antimicrobial effects of Terminalia chebula against antibiotic-resistant pathogens, suggesting its potential as a therapeutic alternative.

Key Points

This review examines the antimicrobial activity and resistance-modifying effects of Terminalia chebula against key bacterial pathogens.
Conducted a systematic review of 24 studies focusing on T. chebula extracts against ESKAPE pathogens.
Performed comprehensive literature searches in databases like PubMed and Scopus following PRISMA guidelines.
Evaluated in vitro activities and mechanisms of resistance modification from various extraction methods.
T. chebula extracts show in vitro antimicrobial activity, particularly against multidrug-resistant S. aureus, P. aeruginosa, and E. coli.
Ethanolic and methanolic extracts demonstrated higher efficacy compared to other forms.
Some studies indicated synergistic effects with antibiotics, hinting at the potential to modify antibiotic resistance pathways.

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Zaman et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f055624 https://doi.org/10.3389/fphar.2026.1855899

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Implication

Systematic review evaluates antimicrobial effects of Terminalia chebula against antibiotic-resistant pathogens, suggesting its potential as a therapeutic alternative.

Terminalia chebula Retz. As a resistance-modifying botanical drug against priority pathogens: a systematic review

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Implication

Key Points

Cite This Study

Terminalia chebula Retz. As a resistance-modifying botanical drug against priority pathogens: a systematic review

Discussion

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Implication

Key Points

Cite This Study

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