In vitro Evaluation of Antiglycation, Antioxidation, and α-Glucosidase Inhibitory Activities of Ethanol Extracts of Terminalia Bellirica and Terminalia Chebula Fruits

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In vitro assessment reveals strong antiglycation and antioxidant effects in traditional fruits, suggesting potential for diabetes management.

TBE shows significantly higher total phenolics and tannins than TCE, indicating better phytochemical content.
Regarding antiglycation activity, TBE demonstrated lower IC50 values for dicarbonyl and AGEs compared to TCE.
Both extracts showed superior α-glucosidase inhibition compared to the standard acarbose, emphasizing their efficacy.
These findings suggest TBE as a promising natural agent for managing oxidative stress-related diabetic complications.

Cushnie et al. (2025) studied this question.

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In vitro assessment reveals strong antiglycation and antioxidant effects in traditional fruits, suggesting potential for diabetes management.